If you get an unknown error when you run it After downloading, do not click 'Run,' but rather click 'Save' and then open the file. After completely uninstalling LOL, reinstall it. Paste by pressing Setting LOL location button.
Copy the Starting Position of the shortcut tab. Right click on the LoL shortcut, then click on properties. FULL FIX: League of Legends won’t launch on Windows 10, 8.1, 7
You can typically test this by temporarily uninstalling them, rebooting once removed and then running the game just once without them to see if the crash no longer occurs.